Analysis on the use of antidepressants in inpatients with depression from 2015 to 2019 / 四川精神卫生

ABSTRACT

ObjectiveTo investigate the use of antidepressants in hospitalized patients with depression disorder from 2015 to 2019， and to analyze the changes of these antidepressants and medication regimens， so as to provide references for clinical drug use. MethodsUsing the Beijing-Tianjin-Hebei big data platform， the data of patients with depression in Beijing Anding Hospital， Capital Medical University from 2015 to 2019 were retrospectively analyzed. The changes of different types of drugs and medication regimens were described. ResultsFrom 2015 to 2019， a total of 6 043 cases of eligible patients were enrolled in analysis. Among selective serotonin reuptake inhibitors （SSRIs）， the prescription proportion of sertraline， citalopram and fluoxetine showed a trend of decline （P<0.05 or 0.01）， while the prescription proportion of escitalopram showed a trend of fluctuations （P=0.031）. In serotonin noradrenaline reuptake inhibitors （SNRIs）， the prescription proportion of duloxetine and milnacipran were rising （P<0.01）. The newer antidepressants agomelatine （P=0.001） and voltioxetine （P<0.01） also showed an upward trend. In terms of medication regimen， the proportion of single antidepressants and combined use of two antidepressants showed a downward trend （P<0.01）， while the proportion of antidepressants combined with mood stabilizers， antidepressants combined with mood stabilizers or antipsychotics showed an upward trend （P<0.05 or 0.01）. ConclusionIn the 5 years， the proportion of SSRIs decreased， and the proportion of SNRIs and newer antidepressants increased in hospitalized patients with depression. The proportion of antidepressants combined with mood stabilizers and antipsychotics in treatment regimens showed an increasing trend.