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Recalibrated scales: The use of low-dose Isotretinoin in a case of Epidermolytic Ichthyosis-NPS1 in a Filipino child
Acta Medica Philippina ; : 592-596, 2021.
Artículo en Inglés | WPRIM | ID: wpr-987813
ABSTRACT
@#Epidermolytic Ichthyosis (EI) is a rare non-syndromic keratinopathic ichthyosis without definitive treatment. This is a case of EI in a 5-year-old Filipino female who presented with hyperkeratotic scales sparing the palms and soles. Histopathology revealed epidermolytic hyperkeratosis. A trial of treatment with isotretinoin 0.3 mg/kg/day, together with keratolytic agents, urea lotion and lactic acid lotion, resulted in a marked decrease in the thickness of the scales and odor. Interestingly, rebound effects were noted at 0.6 mg/kg/day. Taking into account that EI presents with more skin fragility compared to non-EHK ichthyosis, the authors surmise that there may be a smaller treatment window for patients with EI, which is notably lower than recommended for ichthyosis in general.
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Índice: WPRIM (Pacífico Occidental) Asunto principal: Isotretinoína / Hiperqueratosis Epidermolítica Idioma: Inglés Revista: Acta Medica Philippina Año: 2021 Tipo del documento: Artículo

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Índice: WPRIM (Pacífico Occidental) Asunto principal: Isotretinoína / Hiperqueratosis Epidermolítica Idioma: Inglés Revista: Acta Medica Philippina Año: 2021 Tipo del documento: Artículo