The Drug Adherence and Treatment Effect of the Paliperidone Long Acting Injection / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 69-75, 2015.
Artículo
en Coreano
| WPRIM
| ID: wpr-98846
ABSTRACT
OBJECTIVES:
The aim of this study was to examine the drug adherence and treatment effect of the paliperidone long acting injection (LAI) in patients with schizophrenia or other psychotic disorders.METHODS:
We reviewed the medical charts of patients who were prescribed paliperidone LAI from January 2010 to April 2014. Date of each injection, last observation, and first admission after use of the drug were obtained. Kaplan-Meier survival analysis was used for calculation of drug adherence. The dose of paliperidone LAI, concurrent oral antipsychotics, and anticholinergic agent was also obtained. Antipsychotics dose was calculated as olanzapine equivalent dose.RESULTS:
The drug adherence of the paliperidone LAI on day 365 was 65%. The reasons for all cause discontinuation were follow-up loss, no effect, poor insight, rejection, extrapyramidal symptom, pain, etc. A total dose of 9.1 mg of oral antipsychotics was decreased, while the dose of anticholinergic agent was increased.CONCLUSION:
The drug adherence of the paliperidone LAI was 65%, which was concordant with previous studies. The dose of concurrent oral antipsychotics was increased, while the dose of anticholinergic agent was decreased.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trastornos Psicóticos
/
Esquizofrenia
/
Antipsicóticos
/
Estudios de Seguimiento
/
Resultado del Tratamiento
/
Cumplimiento de la Medicación
/
Palmitato de Paliperidona
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Año:
2015
Tipo del documento:
Artículo
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