Advances in butyrates and intestinal immune tolerance in children with cow′s milk protein allergy / 国际儿科学杂志
International Journal of Pediatrics
; (6): 443-446, 2023.
Article
en Zh
| WPRIM
| ID: wpr-989109
Biblioteca responsable:
WPRO
ABSTRACT
Cow′s milk protein allergy is common in infants, which is an abnormal immune reaction caused by the imbalance of intestinal immune tolerance system.Butyrates, the fermentation product of intestinal anaerobic bacteria, can be used as a histone deacetylase inhibitors and a ligand of G protein-coupled receptors to regulate intestinal innate immunity and adaptive immune function, thereby inducing intestinal immune tolerance in children with cow′s milk protein allergy, which has potential clinical therapeutic value for cow′s milk protein allergy.However, this theory is still only based on the exploration of mechanisms at the cellular and animal levels and has not been applied in the clinic.This article reviews the intestinal immune mechanism of cow′s milk protein allergy, the anabolism of butyrates and the important role of butyrates in intestinal immune tolerance of cow′s milk protein allergy, aiming to lay a theoretical foundation for further clinical application of butyrate-induced intestinal immune tolerance of cow′s milk protein allergy.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
International Journal of Pediatrics
Año:
2023
Tipo del documento:
Article