Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
Genomics & Informatics
;
: 59-63, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-98932
ABSTRACT
Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify genetic loci associated with obesity in Asians, we conducted a genome-wide association study (GWAS) of a population of Korean adults (n=6,742, age 40~60 years) and detected six BMI risk loci (TNR, FAM124B, RGS12, NFE2L3, MC4R and FTO) having p<1x10(-5). However, in the replication study, only melanocortin 4 receptor gene (MC4R) (rs9946888, p=4.58x10(-7)) was replicated with marginal significance (p<0.05) in the second cohort (n=5,102, age 40~60 years). This study indicates that each locus associated with BMI has very weak genetic effect.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedades Cardiovasculares
/
Índice de Masa Corporal
/
Estudios de Cohortes
/
Receptor de Melanocortina Tipo 4
/
Pueblo Asiatico
/
Estudio de Asociación del Genoma Completo
/
Sitios Genéticos
/
Obesidad
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Humanos
Idioma:
Inglés
Revista:
Genomics & Informatics
Año:
2011
Tipo del documento:
Artículo
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