Optimization of the extraction process of Shangke Huoxue Granule by central composite design-response surface methodology / 国际中医中药杂志
International Journal of Traditional Chinese Medicine
;
(6): 451-455, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-989642
ABSTRACT
Objective:
To optimize the extraction process of Shangke Huoxue Granule.Methods:
Taking the factors of extraction solvent multiple, extraction time and extraction times as investigation factors, and extraction amount of ferulic acid, paeoniflorin and the ratio of extraction as comprehensive evaluation indices, one-factor experimental design and central composite design-response surface methodology were adopted to optimize the extraction process of Shangke Huoxue Granule.Results:
The binomial fitting equation was Y=96.16+2.42 A+0.63 B-3.76 AB-1.57 A2-1.87 B2 ( P<0.01). The optimal extraction process parameters were confirmed to be adding 16 times of water, 64 minutes each time, twice. The deviation rates between the measured values of three verification experiments and the predicted value were 2.00%, 3.23% and 0.66%.Conclusion:
The established model of central composite design-response surface methodology has high predictability and the optimized extraction process is stable and feasible.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Journal of Traditional Chinese Medicine
Año:
2023
Tipo del documento:
Artículo
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