Research and progression of TRPC6 and proteinuria induced by obesity / 中华内分泌外科杂志

ABSTRACT

The obesity related glomerulopathology attracts more and more attention due to the proteinuria induced by podocyte injury. TRPC6,which on the slit diaphragm of podocyte, and other factors contain together of the signal translation, cell polarization and cell skeleton structure of podocyte. Therefore the ion channels become the research front filed of kidney disease from the view on electrophysiology. Under this background, we introduce the biological function of TRPC6 and review its role on proteinuria induced by obesity. At last we sum up and outlook the application of TRPC6 as a treated target in proteinuria related obesity in the future.