Highly Protective Association of MMP-2-1306C/T Promoter Polymorphism With Asthma in a North Indian Population: A Pilot Study
Allergy, Asthma & Immunology Research
;
: 234-241, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-99069
ABSTRACT
PURPOSE:
Asthma is the most prevalent disease in India according to the national survey conducted by NFHS 2 in 1998-1999. Matrix metalloproteinase-2 (MMP-2), a collagenase encoded by the MMP-2 gene, degrades the type IV collagen and is responsible for inflammatory responses. This is a pilot study evaluating the role of MMP-2 -1306C/T promoter single nucleotide polymorphism (SNP) in asthma pathogenesis.METHODS:
A case-control study was performed with a total of 824 adult subjects, including 410 adult asthmatics and 414 healthy controls from regions of North India. The MMP-2 -1306C/T polymorphism was genotyped by the Tetra-Primer Amplification Refractory Mutation System Polymerase Chain Reaction (Tetra-Primer ARMS PCR).RESULTS:
Statistical analysis of the results for the MMP-2 -1306C/T polymorphism revealed an extremely protective role of the mutant T allele in asthma pathogenesis with OR=0.45, 95% CI (0.35-0.58) and P=0.000. The heterozygous CT genotype also conferred protection from asthma with OR=0.37, 95% CI (0.27-0.51) and P=0.000. The homozygous TT genotype was also significantly associated with asthma with OR=0.35, 95% CI (0.16-0.72) and P=0.002. Moreover, the polymorphism was significantly associated with all the phenotypic traits of the disease.CONCLUSION:
The MMP-2 -1306C/T promoter polymorphism confers significant protection from asthma in the studied North Indian population
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Brazo
/
Asma
/
Estudios de Casos y Controles
/
Proyectos Piloto
/
Reacción en Cadena de la Polimerasa
/
Colagenasas
/
Metaloproteinasa 2 de la Matriz
/
Polimorfismo de Nucleótido Simple
/
Colágeno Tipo IV
/
Alelos
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Allergy, Asthma & Immunology Research
Año:
2014
Tipo del documento:
Artículo
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