Research advances in neuroprotective role of sigma-1 receptor in retina / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology
;
(12): 512-515, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-990876
ABSTRACT
Retinal degenerative diseases are a major contributor to visual impairment worldwide, and research related to retinal degenerative diseases is increasingly becoming a hot topic.The sigma-1 receptor is a 223-amino-acid endoplasmic reticulum transmembrane protein, and its gene sequence is highly conserved throughout mammals.Sigma-1 receptors are widely distributed in various tissues and organs.Numerous studies have proved the protective role of sigma-1 receptors in retinal pathological processes, including anti-oxidative stress, anti-inflammatory response, and anti-apoptosis.In addition, sigma-1 receptors have potential therapeutic roles in retinal diseases, especially diabetic retinopathy, retinitis pigmentosa and glaucomatous neuropathy.In this paper, the molecular mechanisms of sigma-1 receptor-mediated retinal neuroprotection and its application in the treatment of retinal diseases were reviewed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Experimental Ophthalmology
Año:
2023
Tipo del documento:
Artículo
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