Hydronephrotic atrophy after partial ureteral obstruction: Experimental model and natural history / 대한비뇨기과학회지

ABSTRACT

Partial ureteral obstruction was studied in male ICR mice in an attempt to observe the natural history of hydronephrotic atrophy. The left ureter was placed into the left psoas muscle, as descried by Ulm and Miller, to create a partial ureteral obstruction. In partial ureteral obstruction group, there was significant weight reduction of hydronephrotic kidney during the first two weeks. And then there was no further weight reduction. In complete ureteral obstruction group, there was progressive weight reduction and gain in hydronephrotic and contralateral kidney, respectively. These observations lead to conclusion that hydronephrotic atrophy after partial unilateral ureteral obstruction is not a progressive disease but develops in two phases: a destructive phase and a steady state phase.