Antihypertensive Effects of Nilvadipine(Nivadil(R)) in Patients with Essential Hypertension
Korean Circulation Journal
;
: 820-825, 1993.
Artículo
en Coreano
| WPRIM
| ID: wpr-99197
ABSTRACT
BACKGROUND:
Form the 1970's calcium channel blockers have been used as one of the most effective drugs for antihypertensive therapy. Nilvadipine(Nivadil(R)) is a new vessel-selective calcium channel blocker with a markedly high oral bioaviliability and a long elimination half-life time. To evaluate the efficacy and side effects of nilvadipine, daily monotherapy was done in 22 patients with essential hypertension.METHOD:
After more than 2 weeks of previous drug wash-out periods, Nilvadipine 8-12mg was administered daily in 2 or 3 divided dosage for 8 weeks in patients with mild to severe essential hypertension. The sitting blood pressure(BP) and heart rate were measured before and 2, 4, 8 weeks after medication.RESULT:
Systolic and diastolic BP were significantly reduced at 2 weeks after medication and no further significant BP reduction were noted throughout the remainer of the trial(4 to 8 weeks). Normotension(diastolic BP < or =90mmHg) was achieved in 14 cases(67%) after 8 weeks therapy and in 7 cases(33%) BP reduced effectively. The side effect noted were headache and facial flushing in 2 cases and in one of them the medication were discontinued. And fatigue, dizziness were complaint in 1 case respectively. There were no significant laboratory changes before and after nilvadipine therapy.CONCLUSION:
It can be concluded that nilvadipine(Nivadil(R)) monotherapy is effective in many patients with essential hypertension and a clinical study of combined therapy with other antihypertensive agents in larger numbers of patients will be needed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bloqueadores de los Canales de Calcio
/
Canales de Calcio
/
Mareo
/
Fatiga
/
Rubor
/
Semivida
/
Cefalea
/
Frecuencia Cardíaca
/
Hipertensión
/
Antihipertensivos
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Circulation Journal
Año:
1993
Tipo del documento:
Artículo
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