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Antihypertensive Effects of Nilvadipine(Nivadil(R)) in Patients with Essential Hypertension
Korean Circulation Journal ; : 820-825, 1993.
Artículo en Coreano | WPRIM | ID: wpr-99197
ABSTRACT

BACKGROUND:

Form the 1970's calcium channel blockers have been used as one of the most effective drugs for antihypertensive therapy. Nilvadipine(Nivadil(R)) is a new vessel-selective calcium channel blocker with a markedly high oral bioaviliability and a long elimination half-life time. To evaluate the efficacy and side effects of nilvadipine, daily monotherapy was done in 22 patients with essential hypertension.

METHOD:

After more than 2 weeks of previous drug wash-out periods, Nilvadipine 8-12mg was administered daily in 2 or 3 divided dosage for 8 weeks in patients with mild to severe essential hypertension. The sitting blood pressure(BP) and heart rate were measured before and 2, 4, 8 weeks after medication.

RESULT:

Systolic and diastolic BP were significantly reduced at 2 weeks after medication and no further significant BP reduction were noted throughout the remainer of the trial(4 to 8 weeks). Normotension(diastolic BP < or =90mmHg) was achieved in 14 cases(67%) after 8 weeks therapy and in 7 cases(33%) BP reduced effectively. The side effect noted were headache and facial flushing in 2 cases and in one of them the medication were discontinued. And fatigue, dizziness were complaint in 1 case respectively. There were no significant laboratory changes before and after nilvadipine therapy.

CONCLUSION:

It can be concluded that nilvadipine(Nivadil(R)) monotherapy is effective in many patients with essential hypertension and a clinical study of combined therapy with other antihypertensive agents in larger numbers of patients will be needed.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Bloqueadores de los Canales de Calcio / Canales de Calcio / Mareo / Fatiga / Rubor / Semivida / Cefalea / Frecuencia Cardíaca / Hipertensión / Antihipertensivos Límite: Humanos Idioma: Coreano Revista: Korean Circulation Journal Año: 1993 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Bloqueadores de los Canales de Calcio / Canales de Calcio / Mareo / Fatiga / Rubor / Semivida / Cefalea / Frecuencia Cardíaca / Hipertensión / Antihipertensivos Límite: Humanos Idioma: Coreano Revista: Korean Circulation Journal Año: 1993 Tipo del documento: Artículo