Research progress of sepsis-associated acute kidney injury based on Gut-Kidney axis / 中华危重病急救医学
Chinese Critical Care Medicine
;
(12): 329-333, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-992026
ABSTRACT
Sepsis-associated acute kidney injury (SA-AKI), as a common renal dysfunction in sepsis, has become one of the major diseases threatening human health with increasing morbidity and mortality. Based on the theory of "gut-kidney axis", the intestine and kidney have a two-way synergistic relationship in sepsis. Intestinal flora imbalance, endogenous metabolite imbalance, and impaired endothelial barrier integrity are involved in renal injury, and the increase of renal inflammatory mediators interferes with the composition of intestinal microorganisms. Therefore, understanding the intestinal-renal crosstalk mechanism of SA-AKI will help to provide a potential basis for new treatment strategies for SA-AKI.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Critical Care Medicine
Año:
2023
Tipo del documento:
Artículo
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