Research progress on mechanism and protein modification of Beclin1 in autophagy / 中国生物制品学杂志

ABSTRACT

@#Autophagy is a process of self-phagocytosis of lysosomal degrading substances in cells. Under normal conditions,cells can use autophagy to remove their own garbage to provide energy,while in a state of stress,autophagy can also be activated,resulting in cell damage and death,which can seriously lead to cancer. B-cell lymphoma-2-interacting myosin-like coiled-coil protein(Beclin1) is a central node in the autophagy pathway and interacts with a variety of proteins to regulate the formation and maturation of autophagosomes. Kinase mediates the protein modification of Beclin1 during autophagy,which will affect its activity and interaction with other autophagy-related proteins. Beclin1 is closely related to the occurrence and development of tumors. Therefore,this paper focused on the research progress on the mechanism and protein modification of Beclin1 in autophagy,in view to providing a reference for the research of targeted drugs of tumor autophagy.