Advances in research on small molecule regulators targeting HBV cccDNA generation and transcription / 药学学报
Acta Pharmaceutica Sinica
;
(12): 2979-2994, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-999040
ABSTRACT
Hepatitis B virus (HBV) represents a significant global public health challenge. Despite the availability of several approved drugs for hepatitis B treatment, the persistence of covalently closed circular DNA (cccDNA) renders HBV eradication elusive, thereby leading to disease relapse after drug withdrawal. This paper reviews the regulatory mechanisms of cccDNA formation, transcription and replication, and summarizes the research progress of related small molecule regulators from the perspective of medicinal chemistry.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2023
Tipo del documento:
Artículo
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