Subcellular localization of macrophage migration inhibitory factor and its diverse biological functions in tumors / 药学学报
Acta Pharmaceutica Sinica
; (12): 2085-2097, 2023.
Article
en Zh
| WPRIM
| ID: wpr-999152
Biblioteca responsable:
WPRO
ABSTRACT
Macrophage migration inhibitory factor (MIF) is an enzyme-active pleiotropic cytokine that is expressed in various immune cells and tumor cells. MIF plays diverse roles in inflammation and tumor progression. It acts as a cytokine involved in immune response and inflammatory lesions. Additionally, MIF is closely associated with tumor proliferation, metastasis, and other tumor hallmarks, exerting a multifaceted influence on tumor occurrence and progression. MIF not only functions by being secreted into the extracellular space as a cytokine but can also be localized within the cytoplasm and nucleus, exhibiting diverse biological functions. As MIF in promoting tumor progression becomes increasingly recognized, MIF-based therapeutic strategies have become a hot research topic in oncology. Here, we provide a comprehensive review of MIF with different subcellular localization about their pro-tumoral functions. A better understanding of MIF in tumor biology will bring broader perspectives for the development of novel MIF targeting strategies and give promising direction for future tumor treatments.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2023
Tipo del documento:
Article