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The antimicrobial efficacy of multipurpose contact lens solutions on standard strains of common ocular pathogens
Philippine Journal of Ophthalmology ; : 35-42, 2013.
Artículo en Inglés | WPRIM | ID: wpr-999189
ABSTRACT
Objective@#To compare the antimicrobial effects of locally available multipurpose contact lens solutions (MPS) on the growth of standard strains of contact lens-related ocular pathogens and to establish the recommended duration of exposure to these solutions to achieve maximal antimicrobial efficacy.@*Methods@#This study, a single-blind controlled experiment, evaluated five locally available MPS in terms of their antimicrobial efficacy towards common contact lens-related ocular pathogens, such as P. aeroginosa, S. aureus, E. coli, F. solani, and C. albicans, using the stand alone criteria. Microbial viability counts were obtained at serial durations after 1 hour, 3 hours, 6 hours, and 12 hours of exposure.@*Results@#MPS containing polyquaternium-1 and myristamidopropyl dimethylamine (MAPD) and polyhexamide reduced the bacterial concentrations by 3 log and fungal concentrations by 1 log, enabling them to fulfill the stand alone criteria for disinfecting solutions as mandated by ISO/CD 14729. This antimicrobial efficacy was most evident at 6 hours of exposure to the challenge organisms. MPS containing polyquaternium-1 and MAPD also have the broadest spectrum of effectivity against gram-negative and gram-positive bacteria, and C. albicans. All MPS tested have poor microbial activity against F. solani. @*Conclusion@#Multipurpose contact lens solutions demonstrated variability in their antimicrobial activity. MPS with broad spectrum efficacy and effectivity, such as those containing polyquaternum and MAPD, are preferred to prevent contact lens-related ocular infections.
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Índice: WPRIM (Pacífico Occidental) Asunto principal: Lentes de Contacto Idioma: Inglés Revista: Philippine Journal of Ophthalmology Año: 2013 Tipo del documento: Artículo

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Índice: WPRIM (Pacífico Occidental) Asunto principal: Lentes de Contacto Idioma: Inglés Revista: Philippine Journal of Ophthalmology Año: 2013 Tipo del documento: Artículo