Effect and mechanism of serotonin-selective reuptake inhibitor on bone metabolism / 中国药房
China Pharmacy
;
(12): 2928-2933, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-999230
ABSTRACT
Serotonin-selective reuptake inhibitor (SSRI) is the first-line drug for treating depression. SSRI mainly include fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram and escitalopram, etc. SSRI has dual impact on bone metabolism. Short- term use of SSRI may have a positive impact on bone, but long-term use may lead to bone problems. This article summarizes the effects and mechanisms of SSRI on bone metabolism, indicating that SSRI can affect bone formation, bone resorption, mesenchymal stem cell differentiation, and regulate the expression of inflammatory cytokines. The impact of SSRI on bone metabolism can be achieved by affecting classical signaling pathways such as cAMP/PKA/CREB, Wnt/β-catenin, BMP/Smad, OPG/RANKL/RANK, and through centrally mediated effects.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2023
Tipo del documento:
Artículo
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