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Treatment of bisphosphonate-related osteonecrosis using platelet-rich plasma: microtomographic, microscopic, and immunohistochemical analyses
Cardoso, Camila Lopes; Curra, Cláudia; Curi, Marcos Martins; Matsumoto, Mariza Akemi; Argentino, Camila Dionísio; Franzolin, Solange de Oliveira Braga; Constantino, Dulce; Barbosa, Daniela Nicolielo; Ferreira Júnior, Osny.
Affiliation
  • Cardoso, Camila Lopes; Universidade do Sagrado Coração. Department of Oral Surgery. Bauru. BR
  • Curra, Cláudia; Universidade do Sagrado Coração. Department of Oral Surgery. Bauru. BR
  • Curi, Marcos Martins; Hospital Santa Catarina. Department of Stomatology. São Paulo. BR
  • Matsumoto, Mariza Akemi; Universidade Estadual Paulista. Department of Histology. Araçatuba. BR
  • Argentino, Camila Dionísio; Universidade do Sagrado Coração. Department of Oral Surgery. Bauru. BR
  • Franzolin, Solange de Oliveira Braga; Universidade do Sagrado Coração. Department of Health Sciences. Bauru. BR
  • Constantino, Dulce; Universidade do Sagrado Coração. Department of Health Sciences. Bauru. BR
  • Barbosa, Daniela Nicolielo; Universidade do Sagrado Coração. Department of Health Sciences. Bauru. BR
  • Ferreira Júnior, Osny; Universidade de São Paulo. Department of Oral Surgery. Bauru. BR
Braz. oral res. (Online) ; 33: e050, 2019. tab, graf
Article de En | LILACS | ID: biblio-1011654
Bibliothèque responsable: BR1.1
ABSTRACT
Abstract The present study aimed to investigate the use of platelet-rich plasma (PRP) on tooth extraction sites in rats treated with bisphosphonates. Thirty Albinus Wistar male rats were administered 0.035 mg/kg zoledronic acid intravenously for 8 weeks, divided into four administrations with a 2-week interval between each application, after which their upper right central incisors were extracted to induce the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ). The samples were divided into the following two groups Group 1 (G1) underwent marginal resection of BRONJ followed by the use of PRP, while Group 2 (G2) underwent resection of BRONJ but without the use of PRP. The treatment groups were evaluated after 14, 28, and 42 days. Clinical, microtomographic, microscopic, and immunohistochemical (IHC) evaluations were performed. Microtomography results revealed no significant difference between the groups (p <0.05) in any time period. Histomorphometric analysis showed increased bone formation over time for both groups (p < 0.001). G1 demonstrated a greater amount of new bone formation than G2 at 28 and 42 days (p < 0.001), with G1 presenting greater vascularization and a slightly higher VEGF expression. For both groups, RANKL/OPG expression levels were sufficient as a parameter for indicating the rate of bone remodeling in a previously treated area of osteonecrosis groups. Taken together, our findings indicated that the use of PRP improves the resolution process of BRONJ.
Sujet(s)
Mots clés

Texte intégral: 1 Indice: LILACS Sujet Principal: Diphosphonates / Agents de maintien de la densité osseuse / Plasma riche en plaquettes / Ostéonécrose de la mâchoire associée aux biphosphonates Type d'étude: Prognostic_studies Limites du sujet: Animals langue: En Texte intégral: Braz. oral res. (Online) Thème du journal: ODONTOLOGIA Année: 2019 Type: Article

Texte intégral: 1 Indice: LILACS Sujet Principal: Diphosphonates / Agents de maintien de la densité osseuse / Plasma riche en plaquettes / Ostéonécrose de la mâchoire associée aux biphosphonates Type d'étude: Prognostic_studies Limites du sujet: Animals langue: En Texte intégral: Braz. oral res. (Online) Thème du journal: ODONTOLOGIA Année: 2019 Type: Article