Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive rats
Motriz (Online)
;
25(2): e101938, 2019. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1012692
ABSTRACT
Abstract Aim:
The present study aimed to analyze the effects of N-acetylcysteine supplementation associated with concurrent training on the bone mineral density of spontaneously hypertensive elderly rats.Methods:
For the present study, 28 male spontaneously hypertensive rats, six months old, were distributed in the following groups control (C, n=7); control + N-acetylcysteine (CNAC, n=7); concurrent training (T, n=7); and concurrent training+N-acetylcysteine (TNAC, n=7). The concurrent training was composed of aerobic training on a treadmill and resistance training in the same training session, three times a week. Animals of the NAC groups received a dose equivalent to 120 mg/kg/day orally for eight weeks. The animals in the trained groups underwent training for eight weeks. The animals were evaluated at the beginning and end of the experiment. After euthanasia, the tibias and femurs were submitted to bone densitometry analysis in an X-ray dual emission device.Results:
Lower weight variation was observed in the trained animals and a reduction in pressure values in all groups, but without a statistical difference (p> 0.05). The animals in the T and TNAC groups presented a better performance in the physical tests (p <0.05). In relation to bone, the NAC groups demonstrated a decrease in femoral bone density when compared to groups C and T. Finally, all experimental groups demonstrated an increase in tibial bone density, but with no statistical difference (p>0.05).Conclusion:
The animals in group T demonstrated better performance in the physical tests. In addition, the NAC caused a reduction in the bone mineral density of the femur.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Acétylcystéine
/
Densité osseuse
/
Hypertension artérielle
Type d'étude:
Facteurs de risque
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Motriz (Online)
Thème du journal:
EducaÆo F¡sica e Treinamento
/
Medicina Esportiva
/
Medicina F¡sica e ReabilitaÆo
Année:
2019
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Estadual Paulista " Julio de Mesquita Filho"/BR
/
Universidade Estadual Paulista "Julio de Mesquita Filho"/BR
/
Universidade Estadual de Campinas/BR
/
Universidade do Oeste Paulista/BR
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