Reactivation of Chagas disease in a heart transplant patient infected by sylvatic trypanosoma cruzi discrete typing unit I
Rev. Soc. Bras. Med. Trop
;
52: e20180512, 2019. tab
Article
Dans Anglais
| LILACS
| ID: biblio-1013317
ABSTRACT
Abstract Heart transplantation is an effective treatment for Chagas disease patients with severe cardiomyopathy. However, Trypanosoma cruzi reactivation is of great concern. The T. cruzi parasite is classified into six discrete typing units (DTUs identified as TcI-TcVI). It is unknown whether there is an association between T. cruzi genetic lineages and the different clinical manifestations of the disease. We report the case of a 51-year-old man who received a heart transplantation and presented with a reactivation of the disease. The molecular characterization of the parasite showed that the reactivation was related to specific infection by a DTU I (TcISYL) parasite.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Trypanocides
/
Cardiomyopathie associée à la maladie de Chagas
/
Transplantation cardiaque
/
Immunosuppresseurs
/
Nitroimidazoles
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
Médecine tropicale
Année:
2019
Type:
Article
Pays d'affiliation:
Colombie
Institution/Pays d'affiliation:
Instituto Nacional de Salud/CO
/
Universidad Nacional de Colombia/CO
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