Analysis on the risk factors for organ damage in patients with systemic lupus erythematosus: a cross-sectional single-center experience
São Paulo med. j
;
137(2): 155-161, Mar.-Apr. 2019. tab
Article
Dans Anglais
| LILACS
| ID: biblio-1014637
ABSTRACT
ABSTRACT BACKGROUND:
Organ damage in patients with systemic lupus erythematosus (SLE) occurs as a consequence of the disease itself, the therapy applied and the accompanying conditions and complications. Organ damage predicts further organ damage and is associated with an increased risk of death.OBJECTIVE:
This study aimed to assess the degree of irreversible organ changes in SLE patients, using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI); to establish correlations between organ damage and disease activity, quality of life, intensity of fatigue and serological factors; and to ascertain the risk factors for organ damage. DESIGN ANDSETTING:
Cross-sectional single-center study conducted at the Institute for Treatment and Rehabilitation "Niška Banja", Niš, Serbia.METHODS:
83 patients with SLE were enrolled 58 patients formed the group with organ damage (SDI ≥ 1), and 25 patients without organ damage served as controls (SDI = 0).RESULTS:
Organ damage correlated with age (P = 0.002), disease duration (P = 0.015), disease activity (grade 1, P = 0.014; and grade 2, P = 0.007), poor quality of life, severe fatigue (P = 0.047) and treatment with azathioprine (P = 0.037). The following factors were protective use of hydroxychloroquine (P = 0.048) and higher scores obtained for the physical (P = 0.011), mental (P = 0.022) and general health (P = 0.008) domains.CONCLUSION:
It is very important to evaluate risk factors for organ damage in the body, including physicians' overall assessment, to try to positively influence better treatment outcomes.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Évolution de la maladie
/
Fatigue
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Lupus érythémateux disséminé
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude de prévalence
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Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
São Paulo med. j
Thème du journal:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Médicament
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Année:
2019
Type:
Article
Institution/Pays d'affiliation:
University of Kragujevac/RS
/
University of Niš/RS
/
University of Nis/RS
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