Prediction of bone mass changes after successful parathyroidectomy using biochemical markers of bone metabolism in primary hyperparathyroidism: is it clinically useful?
Arch. endocrinol. metab. (Online)
;
63(4): 394-401, July-Aug. 2019. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1019358
ABSTRACT
ABSTRACT Objective To measure type 1 serum amino-terminal propeptide procollagen (P1NP) and type 1 cross-linked C-terminal telopeptide collagen (CTX) before parathyroidectomy (PTX) in PHPT patients, correlating these measurements with bone mineral density (BMD) changes. Subjects and methods 31 primary hyperparathyroidism (HPTP) were followed from diagnosis up to 12-18 months after surgery. Serum levels of calcium, parathyroid hormone (PTH) vitamin D, CTX, P1NP, and BMD were measured before and 1 year after surgery. Results One year after PTX, the mean BMD increased by 8.6%, 5.5%, 5.5%, and 2.2% in the lumbar spine, femoral neck (FN), total hip (TH), and distal third of the nondominant radius (R33%), respectively. There was a significant correlation between BMD change 1 year after the PTX and CTX (L1-L4 r = 0.614, p < 0.0003; FN r = 0.497, p < 0.0051; TH r = 0.595, p < 0.0005; R33% r = 0.364, p < 0.043) and P1NP (L1-L4 r = 0,687, p < 0,0001; FN r = 0,533, p < 0,0024; TH r = 0,642, p < 0,0001; R33% r = 0,467, p < 0,0079) preoperative levels. The increase in 25(OH)D levels has no correlation with BMD increase (r = -0.135; p = 0.4816). On linear regression, a minimum preoperative CTX value of 0.331 ng/mL or P1NP of 37.9 ng/mL was associated with a minimum 4% increase in L1-L4 BMD. In TH, minimum preoperative values of 0.684 ng/mL for CTX and 76.0 ng/mL for P1NP were associated with a ≥ 4% increase in BMD. Conclusion PHPT patients presented a significant correlation between preoperative levels of turnover markers and BMD improvement 1 year after PTX.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Fragments peptidiques
/
Peptides
/
Densité osseuse
/
Parathyroïdectomie
/
Procollagène
/
Collagène de type I
/
Hyperparathyroïdie primitive
Type d'étude:
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Arch. endocrinol. metab. (Online)
Thème du journal:
Endocrinologie
/
Métabolisme
Année:
2019
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Unifesp/BR
/
Universidade Federal de São Paulo/BR
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