Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells
Biol. Res
;
52: 34, 2019. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1019499
ABSTRACT
BACKGROUND:
Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. However, the antitumor mechanism of psoralen is not fully understood. This study aimed to investigate the therapeutic efficacy of psoralen in human hepatoma cell line SMMC7721 and the mechanism of antitumor effects.RESULTS:
Psoralen inhibited proliferation of SMMC7721 in a dose- and time-dependent manner, and promoted apoptosis. Further, psoralen activated the ER stress signal pathway, including the expansion of endoplasmic reticulum, increasing the mRNA levels of GRP78, DDIT3, ATF4, XBP1, GADD34 and the protein levels of GDF15, GRP78, IRE1α, XBP-1s in a time-dependent manner. Psoralen induces cell cycle arrest at G1 phase by enhancing CyclinD1 and reducing CyclinE1 expression. Moreover, TUDC couldn't inhibit the psoralen-induced ER stress in SMMC7721 cells.CONCLUSIONS:
Psoralen can inhibit the proliferation of SMMC7721 cells and induce ER stress response to induce cell apoptosis, suggesting that psoralen may represent a novel therapeutic option for the prevention and treatment hepatocellular carcinoma.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Carcinome hépatocellulaire
/
Prolifération cellulaire
/
Stress du réticulum endoplasmique
/
Psoralène
/
Tumeurs du foie
/
Antinéoplasiques d'origine végétale
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Biol. Res
Thème du journal:
Biologie
Année:
2019
Type:
Article
Pays d'affiliation:
Chine
Institution/Pays d'affiliation:
Shanghai University of Traditional Chinese Medicine/CN
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