Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery
Braz. J. Pharm. Sci. (Online)
;
55: e17105, 2019. tab, graf, ilus
Article
Dans Anglais
| LILACS
| ID: biblio-1019532
ABSTRACT
The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS)/ tripolyphosphatesodium (TPP) and chitosan (CS)/ tripolyphosphatesodium (TPP)-alginate (ALG) nanoparticles were investigated for the prolonged topical ophthalmic delivery of ofloxacin. A modified ionotropic gelation method was used to produce ofloxacin-loaded nanoreservoir systems. The ofloxacin-loaded CS/TPP and CS/TPP-ALG nanoparticles were characterized for particle size, morphology, zeta potential, encapsulation efficiency, subsequent release and corneal penetration study. The designed nanoparticles have a particle size from 113.8 nm to 509 nm and zeta potential from 16.2 mV to 40.3 mV and encapsulation efficiency values ranging from 19.7% to 33.1%. Nanoparticles revealed a release during the first hours, followed by a more gradual drug release. The ofloxacin-loading CS/TPP or CS/TPP-ALG NPs developed are pronounced penetration enhancing effect as compared to OFX solution (5-6.5 times). Thus, these nanoparticles have a strong potential for ocular drug delivery.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Ofloxacine
/
Chitosane
/
Nanoparticules
/
Administration par voie ophtalmique
/
Phénomènes physiologiques oculaires
langue:
Anglais
Texte intégral:
Braz. J. Pharm. Sci. (Online)
Thème du journal:
Farmacologia
/
Teraputica
/
Toxicologia
Année:
2019
Type:
Article
Pays d'affiliation:
Iran
Institution/Pays d'affiliation:
Kermanshah University of Medical Sciences/IR
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