Updating the role of matrix metalloproteinases in mineralized tissue and related diseases
J. appl. oral sci
;
27: e20180596, 2019. graf
Article
Dans Anglais
| LILACS, BBO
| ID: biblio-1019968
ABSTRACT
Abstract Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ranging from accelerating metastatic cells to ectopic vascular mineralization by smooth muscle cells in complementary manner. The tissue inhibitors of MMPs (TIMPs) have an important role in controlling proteolysis. Paired with the post-transcriptional efficiency of specific miRNAs, they modulate MMP performance. If druggable, these molecules are suggested to be a platform for development of "smart" medications and further clinical trials. Thus, considering the pleiotropic effect of MMPs on mammals, the purpose of this review is to update the role of those multifaceted proteases in mineralized tissues in health, such as bone, and pathophysiological disorders, such as ectopic vascular calcification and cancer.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Remodelage osseux
/
Matrix metalloproteinases
/
Matrice extracellulaire
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
J. appl. oral sci
Thème du journal:
Dentisterie
Année:
2019
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Estadual Paulista Júlio de Mesquita Filho/BR
/
Universidade de São Paulo/BR
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