Pinhal virus, a new arenavirus isolated from calomys tener in Brazil
Vector Borne Zoonotic Dis
;
15(11): 694-700, 2015.
Article
Dans Anglais
| LILACS, SES-SP, SESSP-IALPROD, SES-SP, SESSP-IALACERVO
| ID: biblio-1022067
ABSTRACT
Arenavirus Sabiá was originally isolated from a fatal human infection in Brazil, and after the occurrence of the second fatal human case in São Paulo state, epidemiologic and virologic studies were performed in the area where the patient lived, aiming at the identification of the Sabiá natural rodent reservoir. A broadly cross-reactive enzyme-linked immunosorbent assay (ELISA) was used to screen for antibody-positive samples. Antibodies to arenavirus were detected in two of the 55 samples of Calomys tener, and from these results, samples of rodents were analyzed by a broad RT-PCR assay. RT-PCR amplification detected arenavirus sequences in five of the 55 C. tener samples, and sequencing showed that this virus is a distinct form of Sabiá virus. Thus, we describe here the evidence for the circulation of a new arenavirus in Brazil (proposed name Pinhal virus) and its genetic characterization compared to other arenaviruses. This study also suggests C. tener as a probable rodent reservoir for this virus and associates this new virus with the lineage C of New World arenaviruses. Although we have defined some characteristics of this virus, so far, there is no evidence of its involvement in human disease.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Phylogenèse
/
Brésil
/
Réservoirs de maladies
/
Test ELISA
/
Sigmodontinae
/
Arénavirus du Nouveau Monde
/
Infections à Arenaviridae
/
Animaux
/
Anticorps antiviraux
Type d'étude:
Étude pronostique
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Vector Borne Zoonotic Dis
Année:
2015
Type:
Article
Pays d'affiliation:
Argentine
/
Brésil
Institution/Pays d'affiliation:
Faculdade de Medicina de Ribeirão Preto/BR
/
Insituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui-Pergamino/AR
/
Secretaria da Saúde do Estado de São Paulo/BR
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