Association of the ATP-binding Cassette Transporter A1 Gene Polymorphismo with Lipid Profile and Tye 2 Diabetes Mellitus
Prensa méd. argent
;
105(5): 284-292, jun 2019. tab, fig
Article
Dans Anglais
| LILACS, BINACIS
| ID: biblio-1024554
ABSTRACT
Diabetes remains unique among the main non-communicable ailments (NCDs) recognized by the World Health Organization (WHO), apart from the circulatory diseases, tumours, and long-lasting respiratory ailments. The current study aimed to determine the correlation between ABCA1 gene polymorphismo and lipid profile in type 2 diabetes mellitus patients. Serum samples from 100 type 2 diabetes mellitus patients (46 males and 54 females) and 50 standard subjects (26 males and 24 females) were colected from Najaf province/Irak. Fasting blood sugar (FBS), and lipid profiles (total cholesterol (TC), triglycerides (TH), HDL, LDL, and VLDL) were meassured. Plymerase chain reaction (PCR) with the Taq1 enzye was used for the amplification of the ABCA1 gene, which contains 525bp of the AABCA1 gene in the locus V825I. The present study revaled a positive corrrelation between FBS and body mass index (BMI) (r= 0.2390, p= 0.0463), TG (r = 0.1836, p= .01743), and VLDL (r = 0.1836, p = 0.1839). The frequencies of the GG genotype and the G allele were higher in the normal groups compared to the patientes (58% vs. 56% and 70% vs. 67%, respectively); conversely, the frequencies of the AA genotype (18% vs. 22%) and the A allele (30% vs. 33%) were higher in the patients compared to the normal groups. The data also showed a significant relationship between ABCA1 gene polymorphim and both TG and VLDL (P=0.007 for cach). There is relationship between the ABCA1 gene and HDL level. Additiionally, the G allele could be a defensive factor against diabetes mellitus in Iraqi peole (AU)
Indice:
LILAS (Amériques)
Sujet Principal:
Polymorphisme génétique
/
Glycémie
/
Diabète de type 2
/
Membre-1 de la sous-famille A des transporteurs à cassette liant l'ATP
/
Profil génétique
/
Fréquence d'allèle
/
Hypercholestérolémie
Type d'étude:
Facteurs de risque
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Prensa méd. argent
Thème du journal:
Médicament
Année:
2019
Type:
Article
Pays d'affiliation:
Iraq
Institution/Pays d'affiliation:
University of Al-Qadisiyah/IQ
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS