Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs
Braz. J. Pharm. Sci. (Online)
;
55: e17825, 2019. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1039074
ABSTRACT
Antipsychotic Drugs (APDs) are being widely prescribed to treat various disorders, including schizophrenia and bipolar disorder; however, abnormal glucose metabolism and weight gain have been reported with Atypical Anti-Psychotic drugs (AAPDs) that can lead to insulin-resistance and type 2 diabetes mellitus. The study was designed to assess various biochemical parameters including insulin and blood sugar before and after exposure to APDs in order to exclude the involvement of psychiatric disorders and certain other factors in metabolic dysregulations. Fifty seven APDs-naïve patients with first episode psychosis were divided into six groups who received olanzapine, quetiapine, risperidone, aripiprazole, haloperidol or combination of olanzapine with escitalopram and haloperidol. The serum samples were taken before the intake of the first dose and then on follow-up. Decrease in the level of elevated insulin and glucose was observed post-treatment in some patients, while others were observed whose insulin and glucose levels increased post-treatment, yet some patients did not show any disturbance in the insulin and glucose levels. It is concluded that psychiatric disorders by itself, narcotics, cigarette smoking and use of oral snuff may be also be implicated in metabolic dysregulations. The effects of APDs on insulin and glucose in healthy volunteers might be different than in patients with psychiatric disorders.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Neuroleptiques
/
Glucose
/
Insuline
Type d'étude:
Étude pronostique
Limites du sujet:
Adolescent
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. J. Pharm. Sci. (Online)
Thème du journal:
Farmacologia
/
Teraputica
/
Toxicologia
Année:
2019
Type:
Article
Pays d'affiliation:
Pakistan
Institution/Pays d'affiliation:
District headquarter Hospital/PK
/
Institute of Radiotherapy and Nuclear Medicine/PK
/
Khyber Teaching Hospital Peshawar+PK
/
University of Peshawar/PK
/
University of Swabi/PK
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