Smaller left anterior cingulate cortex in non-bipolar relatives of patients with bipolar disorder
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
41(3): 254-256, May-June 2019. tab
Article
Dans Anglais
| LILACS
| ID: biblio-1039095
ABSTRACT
Objective:
Bipolar disorder (BD) is highly heritable. The present study aimed at identifying brain morphometric features that could represent markers of BD vulnerability in non-bipolar relatives of bipolar patients.Methods:
In the present study, structural magnetic resonance imaging brain scans were acquired from a total of 93 subjects, including 31 patients with BD, 31 non-bipolar relatives of BD patients, and 31 healthy controls. Volumetric measurements of the anterior cingulate cortex (ACC), lateral ventricles, amygdala, and hippocampus were completed using the automated software FreeSurfer.Results:
Analysis of covariance (with age, gender, and intracranial volume as covariates) indicated smaller left ACC volumes in unaffected relatives as compared to healthy controls and BD patients (p = 0.004 and p = 0.037, respectively). No additional statistically significant differences were detected for other brain structures.Conclusion:
Our findings suggest smaller left ACC volume as a viable biomarker candidate for BD.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Trouble bipolaire
/
Gyrus du cingulum
/
Hippocampe
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Thème du journal:
Psychiatrie
Année:
2019
Type:
Article
Pays d'affiliation:
États-Unis d'Amérique
Institution/Pays d'affiliation:
Massachusetts General Hospital & Brigham and Women's Hospital/US
/
University of Texas Health Science Center at Houston/US
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