Seronegativity to polio viruses among previously immunized adult candidates to solid organ transplantation
Braz. j. infect. dis
;
22(2): 150-152, Mar.-Apr. 2018.
Article
Dans Anglais
| LILACS
| ID: biblio-1039211
ABSTRACT
ABSTRACT In the current effort to eliminate polio from the world, it is important to recognize and vaccinate susceptible groups, especially immunocompromised patients living in countries where attenuated polio vaccine is still used. In this report, we describe the frequency of protective antibodies in a small sample of adult SOT candidates in whom previous vaccination could be ascertained. Patients included in this report were selected among the participants of an ongoing prospective study carried out at the Reference Center for Special Immunobiologicals of the Evandro Chagas National Institute of Infectious Diseases in Rio de Janeiro, Brazil. Among the first 100 patients enrolled in this study, only seven adult SOT candidates had proven polio vaccination at childhood. Three of these seven patients (43%) had no protective antibody titers to one or more poliovirus subtype before solid organ transplant. Proven childhood vaccination against polio does not reliably provide lifelong protective antibody titers for adult SOT candidates and should not be used as a criterion to analyze the need for vaccination in this population.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Poliomyélite
/
Donneurs de tissus
/
Transplantation d'organe
/
Vaccins antipoliomyélitiques
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. j. infect. dis
Thème du journal:
Maladies transmissibles
Année:
2018
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Instituto Nacional de Infectologia Evandro Chagas/BR
/
Instituto Oswaldo Cruz/BR
/
Universidade Federal do Rio de Janeiro/BR
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