Non-polarized cytokine profile of a long-term non-progressor HIV infected patient
Braz. j. infect. dis
;
22(2): 142-145, Mar.-Apr. 2018. tab
Article
Dans Anglais
| LILACS
| ID: biblio-1039213
ABSTRACT
ABSTRACT The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Production of IL-6, IL-10, TNF-α, IFN-γ, and IL-17 was detected; in contrast IL-4 was identified. Host-related factors could help explain such a level of infection control, namely the differentiated modulation of the cellular immune response and a non-polarized cytokine response of the TH1 and TH2 profiles.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Infections à VIH
/
Cytokines
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Survivants à long terme d'une infection à VIH
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Braz. j. infect. dis
Thème du journal:
Maladies transmissibles
Année:
2018
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Departamento Municipal de Saúde/BR
/
Universidade Federal do Mato Grosso do Sul/BR
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