Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis
Int. braz. j. urol
;
45(5): 901-909, Sept.-Dec. 2019. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1040082
ABSTRACT
ABSTRACT Purpose It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association. Materials and Methods A systematic search of studies on the association between CALCR gene polymorphisms and calcium stone urolithiasis susceptibility was conducted in databases. Results Odds ratios and 95% confidence intervals were used to pool the effect size. Five articles were included in our meta-analysis. Conclusions CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insufficient data to fully confirm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identified in the current meta-analysis.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Récepteurs à la calcitonine
/
Polymorphisme de nucléotide simple
/
Urolithiase
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
/
Revues systématiques évaluées
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Int. braz. j. urol
Thème du journal:
Urologie
Année:
2019
Type:
Article
Pays d'affiliation:
Chine
Institution/Pays d'affiliation:
Fujian Medical University/CN
/
Xiamen University/CN
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