Your browser doesn't support javascript.
loading
Participation of the arcRACME protein in self-activation of the arc operon located in the arginine catabolism mobile element in pandemic clone USA300
Rozo, Zayda Lorena Corredor; Márquez-Ortiz, Ricaurte Alejandro; Castro, Betsy Esperanza; Gómez, Natasha Vanegas; Escobar-Pérez, Javier.
Affiliation
  • Rozo, Zayda Lorena Corredor; Universidad El Bosque. Bacterial Molecular Genetics Laboratory. Bogotá. CO
  • Márquez-Ortiz, Ricaurte Alejandro; Universidad El Bosque. Bacterial Molecular Genetics Laboratory. Bogotá. CO
  • Castro, Betsy Esperanza; Universidad El Bosque. Bacterial Molecular Genetics Laboratory. Bogotá. CO
  • Gómez, Natasha Vanegas; Universidad El Bosque. Bacterial Molecular Genetics Laboratory. Bogotá. CO
  • Escobar-Pérez, Javier; Universidad El Bosque. Bacterial Molecular Genetics Laboratory. Bogotá. CO
Mem. Inst. Oswaldo Cruz ; 112(7): 499-503, July 2017. graf
Article de En | LILACS | ID: biblio-1040573
Bibliothèque responsable: BR1.1
ABSTRACT
ABSTRACT Staphylococcus aureus pandemic clone USA300 has, in addition to its constitutive arginine catabolism (arc) gene cluster, an arginine catabolism mobile element (ACME) carrying another such cluster, which gives this clone advantages in colonisation and infection. Gene arcR, which encodes an oxygen-sensitive transcriptional regulator, is inside ACME and downstream of the constitutive arc gene cluster, and this situation may have an impact on its activation. Different relative expression behaviours are proven here for arcRACME and the arcACME operon compared to the constitutive ones. We also show that the artificially expressed recombinant ArcRACME protein binds to the promoter region of the arcACME operon; this mechanism can be related to a positive feedback model, which may be responsible for increased anaerobic survival of the USA300 clone during infection-related processes.
Sujet(s)
Mots clés

Texte intégral: 1 Indice: LILACS Sujet Principal: Opéron / Arginine / Staphylococcus aureus / Protéines bactériennes / Protéines de liaison à l'ADN Limites du sujet: Humans langue: En Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: MEDICINA TROPICAL / PARASITOLOGIA Année: 2017 Type: Article

Texte intégral: 1 Indice: LILACS Sujet Principal: Opéron / Arginine / Staphylococcus aureus / Protéines bactériennes / Protéines de liaison à l'ADN Limites du sujet: Humans langue: En Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: MEDICINA TROPICAL / PARASITOLOGIA Année: 2017 Type: Article