Comparative genomics reveals diverse capsular polysaccharide synthesis gene clusters in emerging Raoultella planticola
Mem. Inst. Oswaldo Cruz
;
113(10): e180192, 2018. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1040581
ABSTRACT
Raoultella planticola is an emerging zoonotic pathogen that is associated with rare but life-threatening cases of bacteremia, biliary tract infections, and urinary tract infections. Moreover, increasing antimicrobial resistance in the organism poses a potential threat to public health. In spite of its importance as a human pathogen, the genome of R. planticola remains largely unexplored and little is known about its virulence factors. Although lipopolysaccharides has been detected in R. planticola and implicated in the virulence in earlier studies, the genetic background is unknown. Here, we report the complete genome and comparative analysis of the multidrug-resistant clinical isolate R. planticola GODA. The complete genome sequence of R. planticola GODA was sequenced using single-molecule real-time DNA sequencing. Comparative genomic analysis reveals distinct capsular polysaccharide synthesis gene clusters in R. planticola GODA. In addition, we found bla TEM-57 and multiple transporters related to multidrug resistance. The availability of genomic data in open databases of this emerging zoonotic pathogen, in tandem with our comparative study, provides better understanding of R. planticola and the basis for future work.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Polyosides bactériens
/
Génome bactérien
/
Enterobacteriaceae
/
Gènes bactériens
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2018
Type:
Article
Pays d'affiliation:
Taïwan
/
États-Unis d'Amérique
Institution/Pays d'affiliation:
National Chung Cheng University/TW
/
National Taiwan University Hospital/TW
/
Shu-Zen Junior College of Medicine and Management/TW
/
US Department of Energy Joint Genome Institute/US
/
University of California/US
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