Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
Mem. Inst. Oswaldo Cruz
;
113(12): e180328, 2018. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1040588
ABSTRACT
BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Herpès génital
/
Infections à VIH
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Herpèsvirus humain de type 2
/
Gènes viraux
Type d'étude:
Étude pronostique
Limites du sujet:
Femelle
/
Humains
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2018
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Fundação Oswaldo Cruz-Fiocruz/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS