Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis
Mem. Inst. Oswaldo Cruz
;
113(3): 197-201, Mar. 2018. graf
Article
Dans Anglais
| LILACS
| ID: biblio-1040592
ABSTRACT
Visceral leishmaniasis (VL) is fatal if left untreated. Infected dogs are important reservoirs of the disease, and thus specific identification of infected animals is very important. Several diagnostic tests have been developed for canine VL (CVL); however, these tests show varied specificity and sensitivity. The present study describes the recombinant protein rLc36, expressed by Leishmania infantum, as potential antigen for more sensitive and specific diagnosis of CVL based on an immunoenzymatic assay. The concentration of 1.0 μg/mL of rLc36 enabled differentiation of positive and negative sera and showed a sensitivity of 85% and specificity of 71% (with 95% confidence), with an accuracy of 76%.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Protéines de protozoaire
/
Leishmania infantum
/
Maladies des chiens
/
Leishmaniose viscérale
Type d'étude:
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2018
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Estadual Paulista/BR
/
Universidade Federal de São Carlos/BR
/
Universidade de São Paulo/BR
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