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Sporothrix brasiliensis produces the highest levels of oxidative stress in a murine model among the species of the Sporothrix schenckii complex
Mario, Débora Nunes; Schaffer, Larissa Finger; Peroza, Luis Ricardo; Jesus, Francielli Pantella Kunz de; Denardi, Laura Bedin; Fachinetto, Roselei; Alves, Sydney Hartz.
  • Mario, Débora Nunes; Imed. Escola de Saúde. Passo Fundo. BR
  • Schaffer, Larissa Finger; Universidade Federal de Santa Maria. Programa de Pós-Graduação em Farmacologia. Santa Maria. BR
  • Peroza, Luis Ricardo; Universidade Federal de Santa Maria. Programa de Pós-Graduação em Farmacologia. Santa Maria. BR
  • Jesus, Francielli Pantella Kunz de; Universidade Federal de Santa Maria. Programa de Pós-Graduação em Farmacologia. Santa Maria. BR
  • Denardi, Laura Bedin; Universidade Federal de Santa Maria. Programa de Pós-Graduação em Ciências Farmacêuticas. Santa Maria. BR
  • Fachinetto, Roselei; Universidade Federal de Santa Maria. Programa de Pós-Graduação em Farmacologia. Santa Maria. BR
  • Alves, Sydney Hartz; Universidade Federal de Santa Maria. Programa de Pós-Graduação em Ciências Farmacêuticas. Santa Maria. BR
Rev. Soc. Bras. Med. Trop ; 50(4): 554-557, July-Aug. 2017. graf
Article Dans Anglais | LILACS | ID: biblio-1041421
ABSTRACT
Abstract

INTRODUCTION:

We compared indicators of oxidative stress in the tissue of mice infected with strains from Sporothrix schenckii complex.

METHODS:

Mice were inoculated with Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa, Sporothrix mexicana or Sporothrix albicans. The activity of catalase and glutathione were accessed in the liver and spleen.

RESULTS:

Animals infected with S. brasiliensis exhibited splenomegaly and significant decrease in catalase activity, and protein and non-protein thiol content compared to animals infected with the other species.

CONCLUSIONS:

Sporothrix brasiliensis exhibits higher pathogenicity compared to other species of the Sporothrix schenckii complex by increasing oxidative stress in animal tissue.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Rate / Sporotrichose / Stress oxydatif / Foie Limites du sujet: Animaux / Humains Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Rev. Soc. Bras. Med. Trop Thème du journal: Médecine tropicale Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Imed/BR / Universidade Federal de Santa Maria/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Rate / Sporotrichose / Stress oxydatif / Foie Limites du sujet: Animaux / Humains Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Rev. Soc. Bras. Med. Trop Thème du journal: Médecine tropicale Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Imed/BR / Universidade Federal de Santa Maria/BR