Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
Rev. Soc. Bras. Med. Trop
; Rev. Soc. Bras. Med. Trop;51(4): 546-549, July-Aug. 2018. graf
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| ID: biblio-1041472
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ABSTRACT
Abstract INTRODUCTION:
We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers.METHODS:
We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry.RESULTS:
BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells.CONCLUSIONS:
Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Schistosomiase à Schistosoma mansoni
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Anticorps antihelminthe
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Interleukine-2
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Interleukine-10
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Lymphocytes T régulateurs
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Animaux allaités
Limites du sujet:
Animals
langue:
En
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
MEDICINA TROPICAL
Année:
2018
Type:
Article