Antiprotozoal action of synthetic cinnamic acid analogs
Rev. Soc. Bras. Med. Trop
;
51(6): 849-853, Nov.-Dec. 2018. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1041494
ABSTRACT
Abstract INTRODUCTION Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds. METHODS In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined. RESULTS Three analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed. CONCLUSIONS Antiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Plasmodium falciparum
/
Trypanosoma cruzi
/
Cinnamates
/
Leishmania
/
Antiprotozoaires
langue:
Anglais
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
Médecine tropicale
Année:
2018
Type:
Article
Pays d'affiliation:
Brésil
/
Paraguay
Institution/Pays d'affiliation:
Centro para el Desarrollo de Investigación Científica/PY
/
Fundação Oswaldo Cruz/BR
/
Universidade Federal de Rondônia/BR
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