Emergence of aph(3')-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil
Rev. Soc. Bras. Med. Trop
;
52: e20180460, 2019. tab
Article
Dans Anglais
| LILACS
| ID: biblio-1041512
ABSTRACT
Abstract INTRODUCTION:
The objective of this study was to characterize genes of aminoglycoside modifying enzymes (AMEs) in colonizing and infecting isolates of E. aerogenes harboring bla KPC from patients at a public hospital in Recife-PE, Brazil.METHODS:
We analyzed 29 E. aerogenes clinical isolates resistant to aminoglycosides. AMEs genes were investigated by PCR and sequencing.RESULTS:
Colonizing and infecting isolates mainly presented the genetic profiles aac(3)-IIa/aph(3')-VI or ant(2")-IIa/aph(3')-VI. This is the first report of aph(3')-VI in E. aerogenes harboring bla KPC in Brazil.CONCLUSIONS:
The results highlight the importance in establishing rigorous methods for the surveillance of resistance genes, especially in colonized patients.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Enterobacter aerogenes
/
Résistance bactérienne aux médicaments
/
Infections à Enterobacteriaceae
/
Aminosides
/
Antibactériens
Limites du sujet:
Humains
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
Médecine tropicale
Année:
2019
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Estadual de Ciências da Saúde/BR
/
Universidade Federal de Pernambuco/BR
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