Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates
Rev. Soc. Bras. Med. Trop
;
52: e20190089B, 2019. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1041519
ABSTRACT
Abstract INTRODUCTION The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. METHODS Thirty isolates were used to determine the mucoid aspect. Four were selected for analysis of phagocytosis by alveolar macrophages. RESULTS Thirty percent of the samples presented the mucoid phenotype. The phagocytosis rate ranged from 21.5% to 43.43%. Phagocytosis was not correlated with the plasmid profile, but was apparently correlated with mucoid phenotype and antibiotic susceptibility. CONCLUSIONS:
Several virulence factors act in parallel in K. pneumoniae to impair host defense.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Phagocytose
/
Virulence
/
Résistance microbienne aux médicaments
/
Facteurs de virulence
/
Klebsiella pneumoniae
/
Antibactériens
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
Médecine tropicale
Année:
2019
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Estadual de Ciências da Saúde de Alagoas/BR
/
Universidade Federal de Pernambuco/BR
/
Universidade de São Paulo/BR
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