Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales / Diagnostic accuracy of serum protein electrophoresis and free light chain measurements for monoclonal gammopathies
Rev. méd. Chile
;
146(1): 64-67, ene. 2018. tab
Article
Dans Espagnol
| LILACS
| ID: biblio-1043145
ABSTRACT
Background:
International guidelines suggest a screening panel for monoclonal gammopathies that contains serum protein electrophoresis (SPE), free light chain (FLC) measurements and immunofixation. This combination provides the possibility of a timely accurate diagnosis.Aim:
To evaluate the sensibility of a simple screening panel (SPE + FLC). Material andMethods:
We analyzed 191 consecutive serum samples of patients with a suspected monoclonal gammopathy (MG).Results:
Seventy five patients were diagnosed with MG. The sensitivity and specificity of the combination of SPE + FLC for the diagnosis of monoclonal gammopathy were 95% (95% confidence intervals 89-99) and 99% (95% confidence intervals 96-100), respectively.Conclusions:
We were able to validate the international recommendations on the diagnostic accuracy of this simple combination of two tests in serum for monoclonal gammopathy.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Paraprotéinémies
/
Électrophorèse des protéines sanguines
/
Chaines légères des immunoglobulines
Type d'étude:
Etude diagnostique
/
Guide de pratique
/
Étude observationnelle
Limites du sujet:
Humains
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2018
Type:
Article
Pays d'affiliation:
Argentine
/
Chili
Institution/Pays d'affiliation:
Hospital del Salvador/CL
/
The Binding Site/AR
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