New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
Arch. endocrinol. metab. (Online)
;
63(6): 557-567, Nov.-Dec. 2019. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1055021
ABSTRACT
ABSTRACT In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue "global". In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines. Arch Endocrinol Metab. 2019;63(6)557-67
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Récepteur STH
/
Hormone de croissance
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Arch. endocrinol. metab. (Online)
Thème du journal:
Endocrinologie
/
Métabolisme
Année:
2019
Type:
Article
Pays d'affiliation:
États-Unis d'Amérique
Institution/Pays d'affiliation:
Ohio University/US
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