Is rectus abdominis thickness associated with survival among patients with liver cirrhosis? A prospective cohort study
São Paulo med. j
;
137(5): 401-406, Sept.-Oct. 2019. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1059101
ABSTRACT
ABSTRACT BACKGROUND:
Sarcopenia may affect patients with liver cirrhosis and worsen disease outcomes.OBJECTIVES:
To evaluate ultrasound-measured psoas major (PM) and rectus abdominis (RA) thickness for predicting survival among patients with liver cirrhosis. DESIGN ANDSETTING:
Prospective cohort study in a tertiary-level hospital.METHODS:
61 patients with liver cirrhosis were prospectively included during a 15-month period and followed up for at least six months. Cirrhosis was classified using the Child-Pugh score. Sarcopenia was assessed using surrogate parameters handgrip strength (HGS), mid-arm muscle circumference (MAMC) and SGA (subjective global assessment). We used ultrasound to measure RA and PM thickness at admission.RESULTS:
There were 41 men. The patients' mean age was 58.03 ± 10.8 years. 26.22% of them were Child-Pugh A, 45.9% B and 27.86% C. The patients were followed up for 11.9 ± 5.63 months. RA thickness correlated moderately with MAMC (r = 0. 596; P < 0.0001) and HGS (r = 0.515; P < 0.0001) and decreased with increasing SGA class (A, 10.6 ± 2.8 mm; B, 8.3 ± 1.9 mm; C, 6.5 ± 1.9 mm; P < 0.0001). Survival at six months was independently predicted by using the model for end-stage liver disease-serum sodium score (odds ratio, OR 1.305; 95% OR confidence interval 1.083-1.572; P = 0.005). Survival during follow-up was independently predicted by RA thickness (hazard ratio, HR 0.701; 95% HR confidence interval 0.533-0.922; P = 0.011) and ascites (HR 1.876; 95% HR confidence interval 1.078-3.267; P = 0.026). PM thickness did not have any predictive value.CONCLUSIONS:
As a surrogate marker of sarcopenia, RA thickness may predict survival among patients with liver cirrhosis.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Muscle droit de l'abdomen
/
Sarcopénie
/
Cirrhose du foie
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Europe
langue:
Anglais
Texte intégral:
São Paulo med. j
Thème du journal:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Médicament
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Année:
2019
Type:
Article
Pays d'affiliation:
Roumanie
Institution/Pays d'affiliation:
Carol Davila University of Medicine and Pharmacy/RO
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