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Kinetics-like equation for cerebrospinal fluid-blood diffusion models
Rodríguez-Pérez, José Alejandro; Mirabal-Viel, Alejandro; Pérez-del-Vallín, Vanessa; Meijides-Mejías, Christian; Castillo-González, William; Lumpuy-Castillo, Jairo; Dorta-Contreras, Alberto Juan.
  • Rodríguez-Pérez, José Alejandro; Universidad de Ciencias Médicas de La Habana. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). CU
  • Mirabal-Viel, Alejandro; Universidad de Ciencias Médicas de La Habana. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). CU
  • Pérez-del-Vallín, Vanessa; Universidad de Ciencias Médicas de La Habana. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). CU
  • Meijides-Mejías, Christian; Universidad de Ciencias Médicas de La Habana. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). CU
  • Castillo-González, William; Universidad de Ciencias Médicas de La Habana. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). CU
  • Lumpuy-Castillo, Jairo; Universidad de Ciencias Médicas de La Habana. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). CU
  • Dorta-Contreras, Alberto Juan; Universidad de Ciencias Médicas de La Habana. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). CU
Rev. cuba. invest. bioméd ; 38(1): e108, Jan.-Mar. 2019. tab, graf
Article Dans Anglais | LILACS, CUMED | ID: biblio-1093376
ABSTRACT

Introduction:

The diffusion of proteins from the blood to the cerebrospinal fluid is influenced by its molecular weight and by the intrinsic properties and biological properties of the protein.

Methods:

Paired samples of serum and cerebrospinal fluid were taken from normal subjects to quantify albumin and proteins of the lectin pathway of the complement system. The distribution of these with regard to the value of QAlbúmin = (Albumin in serum / albumin in cerebrospinal fluid) was evaluated because this protein is used as a marker of the passage of the barrier.

Results:

It was observed that some of these describe a saturation pattern which resembles the curves that describe the Michaelis-Menten reaction of enzymatic activity. This led to the consideration of two constants that will help to characterize the behavior of these proteins by spreading to the cerebrospinal fluid the maximum Q of the protein, which is the maximum proportion found empirically between the concentrations in blood and cerebrospinal fluid and the value Kcdw which is the value of the average diffusion speed of Q albumin when the semi-maximal value of the Q of the protein under study is obtained.

Conclusions:

Empirically obtained constants will help the characterization and differentiation of the diffusion of these new proteins as they pass from the blood to the cerebrospinal fluid(AU)
Sujets)

Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Liquide cérébrospinal / Protéines du liquide céphalorachidien Limites du sujet: Humains langue: Anglais Texte intégral: Rev. cuba. invest. bioméd Thème du journal: Médicament Année: 2019 Type: Article Pays d'affiliation: Cuba Institution/Pays d'affiliation: Universidad de Ciencias Médicas de La Habana/CU

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Liquide cérébrospinal / Protéines du liquide céphalorachidien Limites du sujet: Humains langue: Anglais Texte intégral: Rev. cuba. invest. bioméd Thème du journal: Médicament Année: 2019 Type: Article Pays d'affiliation: Cuba Institution/Pays d'affiliation: Universidad de Ciencias Médicas de La Habana/CU