Plasma antioxidant substances apparently do not influence the radiodermatitis occurrence / Substâncias antioxidantes do plasma aparentemente não influenciam a ocorrência de radiodermatite
Sci. med. (Porto Alegre, Online)
;
30(1): 35844, 2020.
Article
Dans Anglais
| LILACS
| ID: biblio-1122128
ABSTRACT
AIMS:
Radiation affects not only tumors but also healthy tissues through the increment of oxidative stress. Thus, this study aimed to evaluate the oxidative stress degree as well as non-enzymatic antioxidant defenses in the plasma of patients submitted to radiotherapy and to verify if these parameters are modified in those patients who develop radiodermatitis.METHODS:
Forty-one patients submitted to radiotherapy for treatment of breast cancer were followed. From these patients, plasma samples were obtained at the beginning, in the middle and at the end of the treatment, for analysis of thiobarbituric acid reactive substances (TBARS) and ferric reducing ability of plasma (FRAP).RESULTS:
No significant differences were observed in terms of TBARS and FRAP in plasma harvested from these patients at the beginning and at the middle of the treatment. There was lower incidence of grade two radiodermatitis among patients undergoing radiotherapy with hypofractionated doses. There were no differences in FRAP or TBARS among patients who developed radiodermatitis of any degree in relation to those who did not develop this side effect. No differences of FRAP or TBARS were observed between patients that presented grade two radiodermatitis regarding to the others studied.CONCLUSION:
There was no clear relationship between changes in TBARS or FRAP with the occurrence or severity of radiodermatitis.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Tumeurs du sein
Type d'étude:
Étude de dépistage
langue:
Anglais
Texte intégral:
Sci. med. (Porto Alegre, Online)
Thème du journal:
Medicina
Année:
2020
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Faculdade de Medicina de Marília/BR
/
Universidade de São Paulo/BR
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