Prevention of bone infection after open fracture using a chitosan with ciprofloxacin implant in animal model
Acta cir. bras
; 35(8): e202000803, 2020. tab, graf
Article
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| ID: biblio-1130672
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BR1.1
ABSTRACT
Abstract Purpose To evaluate different concentrations of ciprofloxacin to prevent infection after open fracture contaminated with S. aureus in rats using absorbable local delivery system. Methods Fifty-two Wistar rats were assigned to six groups. After 4 weeks, all animals underwent 99mTc-ceftizoxima scintigraphy evaluation, callus formation measurement and histological analysis. ANOVA, t-Student and Kruskal Wallis were used for quantitative variables statistical analysis, whereas qui square and exact Fisher were used for qualitative variables. Results Treatment using 25% and 50% of ciprofloxacin incorporated at the fracture fixation device were effective in preventing bone infection compared to control group (p<0.05). Chitosan were not effective in preventing bone infection when used alone compared to control group (p>0.05). Histological findings demonstrated bone-healing delay with 50% of ciprofloxacin. No difference in callus formation were observed (p>0.05). Conclusion Local delivery treatment for contaminated open fracture using chitosan with ciprofloxacin is effective above 25%.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Ciprofloxacine
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Prévention des infections
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Consolidation de fracture
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Chitosane
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Fractures du fémur
Type d'étude:
Prognostic_studies
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Qualitative_research
Limites du sujet:
Animals
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Humans
langue:
En
Texte intégral:
Acta cir. bras
Thème du journal:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2020
Type:
Article