Omeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect?
Acta cir. bras
;
35(9): e202000904, 2020. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1130677
ABSTRACT
Abstract Purpose:
To investigate the role of omeprazole and nitrites on the gastric mucosa of rats submitted to specific techniques to induce duodenogastric reflux.Methods:
One hundred and twenty Wistar rats were divided into three groups Group I (n=40) -gastrotomy; Group II (n=40) - duodenogastric reflux after gastrojejunoanastomosis latero-lateral (DGR); Group III (n=40) - retrograde duodenogastric reflux through the pylorus (DGR-P). The groups were divided into 4 subgroups of 10 animals, respectively treated for 16 weeks with water, omeprazole 1.6 mg / rat / day, nitrite 600 mg / kg / day and omeprazole plus nitrite simultaneously.Results:
The proliferative lesions found were squamous hyperplasia - 69.1%, adenomatous hyperplasia in the anastomosis - 29.1% and prepyloric adenomatous hyperplasia - 42.5%. Adenocarcinomas were registered in 7 animals (5.8%) one in Group I (omeprazole plus nitrite), two in Group II (omeprazole and nitrite plus omeprazole) and four in Group III (water, nitrite, omeprazole and omeprazole plus nitrite).Conclusions:
The occurrence of squamous hyperplasia, adenomatous hyperplasia and adenocarcinoma increased after gastrojejunal anastomoses, which cause duodenogastric reflux. The association of omeprazole did not protect the development of proliferative lesions and cancer induced by duodenogastric reflux in rats.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Oméprazole
/
Adénocarcinome
/
Reflux duodénogastrique
/
Inhibiteurs de la pompe à protons
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2020
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Centro Universitário de Faculdades de Ensino Associadas/BR
/
UNICAMP/BR
/
Universidade Estadual Paulista/BR
/
Universidade Estadual de Campinas/BR
/
Universidade do Vale do Sapucaí/BR
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