Impairment of myocardial functions and arterial stiffness in patients with lichen planus
An. bras. dermatol
;
95(2): 180-186, Mar.-Apr. 2020. tab, graf
Article
Dans Anglais
| LILACS, ColecionaSUS
| ID: biblio-1130838
ABSTRACT
Abstract Background:
Lichen planus is a chronic inflammatory mucocutaneous disease. Recent studies have suggested that it is associated with an increased risk of cardiovascular comorbidities.Objective:
The purpose of this study was to assess and compare arterial stiffness and cardiovascular hemodynamics in patients with lichen planus and a healthy control group.Methods:
Fifty-five patients with lichen planus and 42 healthy controls were enrolled. All patients underwent echocardiographic examination, and arterial stiffness was measured using applanation tonometry.Results:
No statistically significant difference was determined between the patient and control groups in terms of arterial stiffness, but stiffness was markedly higher in patients with erosive lichen planus compared to the control group and other patients (p = 0.006, and p = 0.023, respectively). Moderate positive correlation was determined between duration of disease and arterial stiffness. Impairment of systolic and diastolic functions was also determined in patients with lichen planus compared to the control group (p < 0.001, and p = 0.005, respectively). Studylimitations:
Relatively low number of patients.Conclusion:
The positive correlation observed between duration of disease and arterial stiffness in patients with lichen planus suggests that these patients should be followed-up in terms of cardiovascular risk in the presence of resistant and long-term disease, particularly in case of erosive lichen planus.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Maladies cardiovasculaires
/
Rigidité vasculaire
/
Hémodynamique
/
Lichen plan
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
An. bras. dermatol
Année:
2020
Type:
Article
Institution/Pays d'affiliation:
Karadeniz Technical University/TR
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