Analysis of cardiovascular risk and carotid intima-media thickness in patients with psoriasis
An. bras. dermatol
;
95(2): 150-157, Mar.-Apr. 2020. tab
Article
Dans Anglais
| LILACS, ColecionaSUS
| ID: biblio-1130840
ABSTRACT
Abstract Background:
Psoriasis is associated with atherosclerosis and increased cardiovascular risk. Currently, an automated ultrasound, called quantitative intima media thickness, has proven to be a useful method to evaluate subclinical atherosclerosis.Objectives:
To compare increased cardiovascular risk in psoriasis patients receiving two types of treatments Methotrexate and tumor necrosis factor inhibitor and to evaluate the correlation between the Framingham score and quantitative intima media thickness.Methods:
Fifty patients with plaque psoriasis were selected from June 2017 to July 2018, divided into two groups, receiving methotrexate and tumor necrosis factor inhibitor. Measurement of abdominal circumference, blood pressure, body mass index and presence of metabolic syndrome were performed. Afterwards, the patients were evaluated for increased cardiovascular risk with the Framingham score and for the quantitative intima media thickness of the carotid arteries.Results:
The mean age was 54.8 (±12.5) with a slight male predominance (58%). Overall, 84% of the patients had elevated waist circumference, 82% had a body mass index above ideal, and 50% had a metabolic syndrome. For the correlation between quantitative intima media thickness and Framingham Score, Pearson's linear correlation coefficient was 0.617 (p < 0.001), indicating a moderate to strong positive association. Studylimitations:
The protective effect of the therapies cited in relation to the increased cardiovascular risk was not evaluated.Conclusions:
A moderate to strong positive association was found correlating the Framingham Score values with the quantitative intima media thickness measurement and it is not possible to state which drug has the highest increased cardiovascular risk.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Psoriasis
/
Maladies cardiovasculaires
/
Méthotrexate
/
Produits dermatologiques
/
Épaisseur intima-média carotidienne
/
Inhibiteurs du facteur de nécrose tumorale
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
An. bras. dermatol
Année:
2020
Type:
Article
Institution/Pays d'affiliation:
Faculdade de Medicina São Leopoldo Mandic/BR
/
Hospital da Pontifícia Universidade Católica de Campinas/BR
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